Anthony Jeselnik, Amy Schumer, Nick Kroll Shows get Comedy Central premiere dates






NEW YORK (TheWrap.com) – Comedy Central has set premiere dates for new series starring comedians Anthony Jeselnik, Amy Schumer, Nick Kroll, Ben Hoffman and Nathan Fielder.


The biting Jeselnik and Schumer are familiar to fans of Comedy Centrals celebrity roasts: They reliably deliver some of the most scathing and best-assembled insults. Nick Kroll stars on FX’s “The League.” And Hoffman and Fielder will both lure unassuming, regular people into their shows, airing together on Thursdays.






Comedy Central made the announcements as it released its midseason schedule Tuesday.


The sketch series “Kroll Show” premieres Wednesday, January 16 at 10:30 p.m. “The Jeselnik Offensive” debuts Tuesday, February 19 at 10:30 p.m., and will take on the week’s train wrecks in the news.


The sketch/man on the street series “The Ben Show,” starring Hoffman, premieres Thursday, February 28 at 10 p.m. It will be followed at 10:30 by Fielder’s “Nathan For You,” which “draws real people into an experience far beyond what they signed up for, according to Comedy Central.


Schumer looks at “sex, relationships, and the general clusterf— that is life” in “Inside Amy Schumer,” beginning Tuesday, April 30 at 10:30 p.m.


The network also announced standup specials for Jeselnik on Sunday, January 13, Kristen Schaal on Friday, January 18, and Katt Williams on Saturday, February 23. (Williams has popped up lately for a string of run-ins with the law, but he’s also famous for telling jokes.)


Comedy Central also set several return dates. Roastmaster Jeff Ross is back for season 2 of “The Burn With Jeff Ross” on Tuesday, January 8 at 10:30 p.m. “Workaholics” clocks in again on Wednesday, January 16 at 10 p.m., and the fifth season of “Tosh.0″ premieres Tuesday, February 5 at 10 p.m.


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AstraZeneca partners with Isis Pharma to develop cancer therapies






(Reuters) – Isis Pharmaceuticals Inc struck a deal with British drugmaker AstraZeneca Plc to develop its novel technology against five cancer targets.


In exchange for $ 31 million in upfront and near-term payments to Isis, AstraZeneca will co-develop four oncology research programs and get the rights to develop and commercialize a drug that is in early trials for patients with advanced lymphomas.






Isis’s antisense therapies work by destroying the RNA that creates proteins involved in disease processes.


“Isis’ antisense technology platform allows AstraZeneca to broaden our oncology research efforts beyond traditional drug discovery methods, while at the same time becoming more specific about how we target cancer,” said Susan Galbraith, head of the AstraZeneca Oncology Innovative Medicines Unit.


Isis is also eligible to receive further payments on clinical and approval milestones, license fees for research program targets and royalties on sales.


Shares of Isis rose about 2 percent before the bell. They closed at $ 9.42 on Monday on the Nasdaq.


(Reporting by Prateek Kumar; Editing by Saumyadeb Chakrabarty)


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Defiant North Korea launches long-range rocket



United States officials confirm that North Korea appears to have carried out the successful launch of a long-range rocket.



The move comes as a surprise to the international community, which has consistently called on North Korea to abandon its efforts.



Less than 24 hours earlier, the North Koreans had indicated they were grappling with "technical uncertainties" that forced them to extend the launch window to Dec. 29.



The secretive regime insists its efforts are part of a peaceful space program intended to place a satellite into orbit. But the U.S. and key Asian allies believe it is a thinly disguised attempt to test an intercontinental ballistic missile aimed at furthering development of the technology needed to mount a nuclear warhead on a long-range rocket that could one day reach the U.S.



National Security Council spokesman Tom Vietor called the launch a "highly provocative act that threatens regional security."



In recent weeks even China, North Korean's only remaining ally, sent a high level delegation into Pyongyang to convey a message of constraint. Today, China expressed "regret" over the incident. In the past, China has supported North Korea's right to develop its space program.



"The action is yet another example of North Korea's pattern of irresponsible behavior," read the National Security Council statement. "The United States remains vigilant in the face of North Korean provocations and is fully committed to the security of allies in the region."



North American Aerospace Defense Command (NORAD) acknowledged the launch initiated at 9:49 a.m. local time and followed its intended trajectory, traveling south between Korea and Japan.



"At no time was the missile or the resultant debris a threat to North America," said NORAD.



Japan's emergency alert system – M-NET – recorded the rocket's flight path directly over Okinawa just after 10:00 a.m. Officials say they have located three points of debris: One in South Korea's Yellow Sea, a second location further down the country's west coast and the third point 180 miles north of the Philippines.



A South Korean military official confirmed that one of their three warships, equipped with the Aegis radar system, detected the launch. The first stage fell just below Byeonsanbando, southwest of the Korean peninsula, exactly where it was supposed to, according to the official.



Increased attention focused on North Korea in recent weeks as satellite images showed action at the Tongchang-ri launch site. But on Monday, a statement from the Korean Committee of Space Technology claimed that scientists and technicians "found a technical deficiency in the first-stage control engine module of the rocket carrying the satellite." Satellite images also revealed that a new third-stage booster was delivered to the launch pad on Saturday.



A key issue is how far the rocket traveled and whether it was able to successfully separate its second and third stage rockets. If so, the capacity to travel long distances would be greatly enhanced.



The type of rocket is believed to be the Taepodong 2 missile. The North Koreans refer to it as the Unha-3, which in Korean translates as "Galaxy-3." The same type of missile has been previously tested three times in 2006, 2009 and 2012. Each time, the rocket failed soon after launch. It is believed to have the capacity to travel a minimum of 3,400 miles. That puts it well within striking range of the western U.S.




The U.S. had mobilized four warships in the Asia-Pacific region to monitor the launch. The guided missile destroyers the USS John S. McCain, the USS Benfold and the USS Fitzgerald joined the guided missile cruiser the USS Shiloh to "reassure allies in the region" according to officials.



South Korea's president Lee Myung-bak called an emergency security meeting in response. The timing is particularly sensitive for this country which is still officially at war with North Korea.



In just one week, South Korea holds key elections and will choose a new president. North Korea's successful launch could potentially sway voters favoring either a harsher line or a return to the "Sunshine Policy" of past administrations.



Current ruling party candidate Park Geun-hye has indicated a willingness to hold talks with North Korea.



Her father, Park Chung-hee, served as the South Korean president for 16 years. He was the target of multiple assassination attempts by North Korea. One of those efforts killed his wife, Chung-hee's mother.



Park took over her mother's duties as first lady until her father was assassinated by the chief of security in 1979. She re-emerged in 1997 as an active politician and is the first female candidate to be seriously considered for president.



Her party, the Saenuridang, is a traditionally conservative group that adapts a somewhat stricter policy towards North Korea that her opponent, Moon Jae-in. As head of the Democratic United Party, he champions a more lenient approach to the South's belligerent neighbor.



In repeated breaking news announcements throughout the day North Korean state-run television celebrated the launch. "We are proud of the glorious success of our satellite technology," said the presenter. "This is a landmark achievement."



Dec. 17 marks the one year anniversary of the country's Dear Leader Kim Jong-il's death. Analysts believe his son and successor, Kim Jong-Un, is under pressure to show the world he is intent on continuing his father's "Military First" policy and demonstrate a show of strength.



While experts do not believe North Korea currently has the technology to mount a nuclear warhead, today's launch is a significant development for the closed country's new leader.

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Australian prank call radio to donate profits to nurse’s family






CANBERRA (Reuters) – The Australian radio station behind a prank call to a British hospital will donate its advertising revenue until the end of the year to a fund for the family of the nurse who apparently took her own life after the stunt, the company said on Tuesday.


Southern Cross Austereo, parent company of Sydney radio station 2Day FM, said it would donate all advertising revenue, with a minimum contribution of A$ 500,000 ($ 525,000), to a memorial fund for the nurse, Jacintha Saldanha, who answered the telephone at the hospital treating Prince William’s pregnant wife, Kate.






The company has suspended the Sydney-based announcers, Mel Greig and Michael Christian, scrapped their “Hot 30″ programme and suspended advertising on the station in the wake of the Saldanha’s death. Southern Cross said it would resume advertising on its station from Thursday.


“It is a terrible tragedy and our thoughts continue to be with the family,” Southern Cross Chief Executive Officer Rhys Holleran said in a statement.


“We hope that by contributing to a memorial fund we can help to provide the Saldanha family with the support they need at this very difficult time.”


(Reporting by James Grubel; Editing by Robert Birsel)


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AstraZeneca starts mid-stage TB drug trial in South Africa






LONDON (Reuters) – A new experimental drug that may fight drug-resistant strains of the lung disease tuberculosis is being tested in South Africa, where the first patient has been enrolled into a mid-stage clinical trial.


AstraZeneca, which developed the medicine known as AZD5847, is working with the U.S. National Institute of Allergy and Infectious Diseases and Case Western Reserve University School of Medicine on the Phase IIa clinical study.






Scientists have found an alarming number of cases of TB that are resistant to many of the most powerful existing antibiotic drugs, underlining the need for new treatments.


AstraZeneca’s new drug is still several years from reaching the market. Even if it works in the trial, further tests will still be needed before it is approved for use.


The British drugmaker said on Tuesday it planned to test AZD5847 in further clinical trials as part of one or more next-generation combination therapies against TB.


(Reporting by Ben Hirschler; Editing by Helen Massy-Beresford)


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Can Obama avoid the 'second-term curse'?


By Jeff Greenfield



Poor Barack Obama. After fighting and spending his way to a close but clear re-election, he’s doomed to four years of agony thanks to that “second-term” curse, which afflicts just about every president who has had the misfortune to win another four years.



The litany appears compelling: the martyred Lincoln; Grant mired in scandal; FDR suffering big political setbacks; Nixon’s disgrace; Reagan’s Iran-Contra scandal; Clinton’s impeachment; George W. Bush’s collapsing popularity. A second term sounds so unappealing, it’s almost surprising Obama didn’t ask for a recount.



Except…there are two things worth remembering about this “curse.” First, it doesn’t really afflict every second-term president. Second, for many presidents, the woes are rooted in actions and decisions taken during the first term—which raises a dicey question about what might come to afflict this president.



Theodore Roosevelt was enormously popular throughout his “second” term (his “first” term was finishing the assassinated William McKinley’s second). The only reason he did not win an actual second term was that, just after his 1904 landslide, he’d declared he would not run again—a decision he regretted almost immediately. (He ran again in 1912 as a third-party candidate, finishing second.)



Calvin Coolidge, elected in a landslide after assuming the presidency when Warren Harding died, presided over four years of peace and prosperity. He stepped down after, declaring, “I do not choose to run for president in 1928.”



Dwight Eisenhower’s Republican Party did suffer serious election reversals in the 1958 mid-terms, but Ike’s personal popularity remained very high in his second term; he left with a 59 percent job approval rating, and his vice president came within a whisker of succeeding him.



What about more recent examples? Reagan’s popularity took a hit when the Iran-Contra story surfaced at the end of 1986, but by the time he left office, he had a robust 63 percent job approval rating, and his vice president won a solid popular vote victory and an electoral college landslide.



And the disgraced Clinton? It’s certainly plausible that his year-long fight to survive scandal and impeachment seriously weakened him. His dependence on his base may have made it impossible for him to reach across the aisle on entitlement reform. But he left office with a 66 percent job approval, and his vice president did win the popular vote.



It’s often said that a second-term victory gives a president an exaggerated sense of his own power, leading him to commit the sin of “hubris” that is always the precursor to tragedy. And history offers examples, from FDR’s attempt to pack the Supreme Court, to George W. Bush’s attempt to partially privatize Social Security.



But take a step back and you’ll find a surprisingly neglected aspect of this history: In many cases, it was what a president did before re-election that planted the seeds of disaster.



Look at Vietnam. The escalation of that conflict began early in 1965, with the bombing of the North and the infusion of large numbers of U.S. troops. But the foundation of that escalation came in the summer of 1964, in the Gulf of Tonkin, when an (almost certainly phantom) attack on U.S. ships led LBJ to win, from a credulous Congress, the Gulf of Tonkin Resolution, authorizing the president to use “all necessary force”—which Johnson interpreted as a virtual blank check.



Watergate? The story exploded early in Nixon’s second term, in the courtroom of Judge John Sirica. But the Watergate break-in and the allied sins of the White House “plumbers’ unit” all took place in the president’s first term—in large measure, to ensure that he’d win again.



The Clinton impeachment? Monica Lewinsky came to the White House as an intern pressed into service because of the government shutdown of 1995. Her affair with the president ended before his second inauguration.



For Bush, the central disaster of his second term was the descent of Iraq into civil war and chaos, and the collapse of the rationale for going into Iraq in the first place—those non-existent weapons of mass destruction. That invasion and the breathtaking failures of intelligence and strategy were rooted in the decisions made in 2002-03.



So, if we’re wise to look at first-term decisions that may come to haunt a second term, what’s the most likely source of future Obama nightmares?



They come, I think, mostly from abroad, where the potential for instability, violence and anti-American hostility could make presidential decisions look very bad. Imagine Egypt turning increasingly Islamist, with a besieged President Morsi—or a successor—repudiating the peace treaty with Israel that has kept the region free of all-out war for 40 years.



Imagine Iraq exploding into a new civil war, or aligning itself with a still-governing Assad in Syria, or with Iran. How would that make Obama’s decision to withdraw from the country look? Pakistan—America’s permanent “frenemy”—is always a step away from turning into a hostile, terrorist-friendly, nuclear power. That step would throw a harsh light on U.S. policy toward that nation.



Should any of those events transpire, expect to hear renewed cries that “the curse of the second term” has struck again. But before joining the chorus, take a hard look at where the trouble really began.



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McAfee wants to return to US, ‘normal life’






BACALAR, Mexico (AP) — Software company founder John McAfee said Sunday he wants to return to the United States and “settle down to whatever normal life” he can.


In a live-stream Internet broadcast from the Guatemalan detention center where he is fighting a government order that he be returned to Belize, the 67-year-old said “I simply would like to live comfortably day by day, fish, swim, enjoy my declining years.”






Police in neighboring Belize want to question McAfee in the fatal shooting of a U.S. expatriate who lived near his home on a Belizean island in November.


The creator of the McAfee antivirus program again denied involvement in the killing during the Sunday Internet video hook-up, during which he answered what he said were reporters’ questions.


His comments were sometimes contradictory. McAfee is an acknowledged practical joker who has dabbled in yoga, ultra-light aircraft and the production of herbal medications.


The British-born McAfee first said that returning to the United States “is my only hope now.” But he later added, “I would be happy to go to England, I have dual citizenship.”


He was emphatic that “I cannot ever return to Belize …. there is no hope for my life if I am ever returned to Belize.”


“If I am returned,” he said, “bad things will clearly happen to me.”


He descibed the health problems that had him briefly hospitalized earlier this week after Guatemalan authorities detained him for entering the country illegally. He apparently snuck in across a rural, unguarded spot along the border.


“I did not eat for two days, I drank very little liquids, and for the first time in many years I’ve been smoking almost non-stop,” he said. “I stood up, passed out hit my head on the wall, came to,” though he now said he was feeling better.


McAfee praised the role his 20-year-old Belizean girlfriend, Samantha Vanegas, played in his escape from Belize, where he claims he is being persecuted by corrupt politicians. Authorities in Belize deny that they are persecuting him and have questioned his mental state.


“Sam saved the day many times” during their escape, he said, and suggested he would take her with him to the United States if he is allowed to go there.


He confirmed that journalists from Vice magazine who accompanied him on his escape after weeks of hiding in Belize had unwittingly posted photos with embedded data that revealed his exact location.


“It was an error anyone could make,” he said, noting they were under a lot of pressure at the time.


McAfee has led an eccentric life since he sold his stake in the anti-virus software company named after him in the early 1990s and moved to Belize about three years ago to lower his taxes.


He told The New York Times in 2009 that he had lost all but $ 4 million of his $ 100 million fortune in the U.S. financial crisis. However, a story on the Gizmodo website quoted him as describing that claim as “not very accurate at all.”


McAfee’s Guatemalan attorney, Telesforo Guerra, says that he has filed three separate legal appeals in the hope that his client can stay in Guatemala, where his political asylum request was rejected.


Guerra said he filed an appeal for a judge to make sure McAfee’s physical integrity is protected, an appeal against the asylum denial and a petition with immigration officials to allow his client to stay in this Central American country indefinitely.


The appeals could take several days to resolve, Guerra said. He added that he could still use several other legal resources but wouldn’t give any other details.


Fredy Viana, a spokesman for the Immigration Department, said that before the agency looks into the request to allow McAfee to stay in Guatemala, a judge must first deal with the appeal asking that authorities make sure McAfee’s physical integrity is protected.


“We won’t look into (allowing him to stay) until the other appeal is resolved,” Viana said. “The law gives me 30 days to resolve the issue.”


McAfee went on the run last month after Belizean officials tried to question him about the killing of Gregory Viant Faull, who was shot to death in early November.


McAfee acknowledges that his dogs were bothersome and that Faull had complained about them, but denies killing Faull. Faull’s home was a couple of houses down from McAfee’s compound in Ambergris Caye, off Belize’s Caribbean coast.


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Gabrielle Aplin tops UK charts with Power of Love






LONDON (Reuters) – English singer Gabrielle Aplin scored her first British number one on Sunday with a cover of the Frankie Goes To Hollywood hit “The Power of Love”, the Official Charts Company said.


Aplin climbed to number one from sixth place with the song, which first entered the charts in 1984 and is the theme for a Christmas television advert for British retailer John Lewis.






In the album charts, Olly Murs, a former runner-up in television’s X-Factor talent contest, held on to the top spot with his release “Right Place Right Time”, but saw his “Troublemaker” slip to third place in the singles ranks.


American singer Pink was the week’s highest climber in the singles top ten, jumping to eighth place from number 26 with “Try”.


(Reporting by Tim Castle; editing by Jason Webb)


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Iron may prevent behavioral issues in small babies






NEW YORK (Reuters Health) – Iron supplements may help boost brain development and ward off behavioral problems in babies who are born a bit on the small side, a new study from Sweden suggests.


Low birth-weight babies are more likely to end up iron deficient, researchers said. They need more of the nutrient for catch-up growth and haven’t stored as much as other babies if they’re also born premature.






For that reason, very early-term and very small babies are often put on iron – but less research has looked at babies born just shy of normal weight, to see if they are also at risk.


“I think this further solidifies the evidence that it’s a very good idea to give these (marginally low birth-weight) children iron supplements,” said Dr. Magnus Domellof, from Umea University, who worked on the study.


The research was led by his colleague, Dr. Staffan Berglund. Their team followed 285 infants born between 4 pounds, 7 ounces and 5 pounds, 8 ounces.


When the babies were six weeks old, the researchers randomly assigned them to get iron drops – either one or two milligrams per kilogram of body weight – or iron-free placebo drops each day until their six-month birthday.


Then at age three and a half, Domellof’s team brought the kids back for IQ tests and surveyed parents about their behavioral issues. The researchers compared kids in the iron- and placebo-drop study groups with another 95 children who were born at normal weight.


There were no IQ differences based on whether the smaller-than-average babies had been put on an iron regimen. All three low birth-weight groups had average scores between 104 and 105. (“Cognitive impairment” in this study was considered an IQ under 85.)


However, significantly more babies given placebo drops had behavioral problems, as reported by their parents. The issues included problems managing emotional reactions, anxiety and depression, as well as sleep and attention problems.


Almost 13 percent of the placebo-group babies scored above the cutoff for clinical behavior problems, versus about 3 percent of kids who’d taken iron drops and kids from the normal-weight comparison group.


That suggests iron deficiency in infancy may be a direct cause of behavioral problems later in childhood, the researchers wrote Monday in the journal Pediatrics.


They are continuing to monitor the same group of kids as they get older, to see if new cognitive or behavioral problems develop or old ones get better as the children head into grade school.


Domellof said he and his colleagues didn’t see any extra stomach problems in kids or delayed growth linked to the use of iron drops. Some research has suggested giving excessive iron to young kids who aren’t deficient may stunt their development.


But, “I would not be afraid of recommending this to all children (born) below 2,500 grams (5 pounds, 8 ounces) at this dose,” Domellof told Reuters Health.


“Here’s where an ounce of prevention is worth a pound of cure,” said Dr. Michael Georgieff, a child development researcher at the University of Minnesota in Minneapolis who had reviewed the study as part of Berglund’s dissertation committee.


He told Reuters Health that it’s important for all parents to know their baby’s iron requirements when they leave the hospital.


“The issue with these marginally low birth-weight infants is, people really haven’t paid a lot of attention to them, but the evidence is accumulating that they are at risk for behavioral problems and less than ideal cognitive function,” said Dr. Betsy Lozoff, who studies the effects of iron deficiency in infants at the University of Michigan in Ann Arbor.


For most babies in the United States, extra iron is recommended starting at four to six months, either through supplements if the mother is breastfeeding or through formula. Very small or premature babies typically have their iron monitored from birth.


But Lozoff, who wasn’t involved in the new research, said that in many places, there are no recommendations for how to treat babies who are just below a normal birth weight.


“This would suggest that it should just be a routine supplementation, and it can be at a low level of iron,” she told Reuters Health.


SOURCE: http://bit.ly/cxXOG Pediatrics, online December 10, 2012.


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Obama, Boehner meet face-to-face on 'fiscal cliff'



For the first time in more than three weeks, President Obama and House Speaker John Boehner met face-to-face Sunday at the White House to talk about avoiding the fiscal cliff.



White House Principal Deputy Press Secretary Josh Earnest would offer no details saying only, "The lines of communication remain open."



Erskine Bowles, the co-creator of a debt reducing plan, who was pessimistic a couple weeks ago, said he likes what he's hearing.



"Any time you have two guys in there tangoing, you have a chance to get it done," Bowles said on CBS's "Face the Nation."



The White House afternoon talks, conducted without cameras or any announcement until they were over, came as some Republicans were showing more flexibility about approving higher tax rates for the wealthy, one of the president's demands to keep the country from the so-called fiscal cliff -- a mixture of across-the-board tax increases and spending cuts that many economists say would send the country back into recession.



"Let's face it. He does have the upper hand on taxes. You have to pass something to keep it from happening," Sen. Bob Corker of Tennessee said on "FOX News Sunday."



This comes after the White House moderated one of its demands about tax rate increases for the wealthy.



The administration was demanding the rate return to its former level of 39.6 percent on income above $250,000. The so-called Bush tax cut set that rate at 35 percent. But Friday, Vice President Joe Biden signaled that rate could be negotiable, somewhere between the two.



"So will I accept a tax increase as a part of a deal to actually solve our problems? Yes," said Oklahoma Republican Tom Coburn on ABC's "This Week."



The problems the senator was referring to are the country's entitlement programs. And there was some progress on that front, too.



A leading Democrat said means testing for Medicare recipients could be a way to cut costs to the government health insurance program. Those who make more money would be required to pay more for Medicare.



"I do believe there should be means testing, and those of us with higher income and retirement should pay more. That could be part of the solution," Sen. Dick Durbin of Illinois said on NBC's "Meet the Press."



But Durbin said he would not favor raising the eligibility age from 65 years old to 67 years old, as many Republicans have suggested.



The White House and the speaker's office released the exact same statement about the negotiating session. Some will see that as a sign of progress, that neither side is talking about what was said behind closed doors.

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